Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Modulation of RNA Condensation by the DEAD-Box Protein eIF4A.

Tauber, Devin; Tauber, Gabriel; Khong, Anthony; Van Treeck, Briana; Pelletier, Jerry; Parker, Roy.

Cell ; 180(3): 411-426.e16, 2020 02 06.

Artigo em Inglês | MEDLINE | ID: mdl-31928844

2.

The Organizing Principles of Eukaryotic Ribosome Recruitment.

Pelletier, Jerry; Sonenberg, Nahum.

Annu Rev Biochem ; 88: 307-335, 2019 06 20.

Artigo em Inglês | MEDLINE | ID: mdl-31220979

3.

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer.

Cencic, Regina; Im, Young K; Naineni, Sai Kiran; Moustafa-Kamal, Mohamed; Jovanovic, Predrag; Sabourin, Valerie; Annis, Matthew G; Robert, Francis; Schmeing, T Martin; Koromilas, Antonis; Paquet, Marilène; Teodoro, Jose G; Huang, Sidong; Siegel, Peter M; Topisirovic, Ivan; Ursini-Siegel, Josie; Pelletier, Jerry.

Proc Natl Acad Sci U S A ; 121(4): e2318093121, 2024 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-38232291

4.

Amygdala inhibitory neurons as loci for translation in emotional memories.

Shrestha, Prerana; Shan, Zhe; Mamcarz, Maggie; Ruiz, Karen San Agustin; Zerihoun, Adam T; Juan, Chien-Yu; Herrero-Vidal, Pedro M; Pelletier, Jerry; Heintz, Nathaniel; Klann, Eric.

Nature ; 586(7829): 407-411, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-33029009

5.

Exploring the targeting spectrum of rocaglates among eIF4A homologs.

Naineni, Sai Kiran; Cencic, Regina; Robert, Francis; Brown, Lauren E; Haque, Minza; Scott-Talib, Jordan; Sénéchal, Patrick; Schmeing, T Martin; Porco, John A; Pelletier, Jerry.

RNA ; 29(6): 826-835, 2023 06.

Artigo em Inglês | MEDLINE | ID: mdl-36882295

6.

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation.

Xu, Zhang; Choi, Jung-Hyun; Dai, David L; Luo, Jun; Ladak, Reese Jalal; Li, Qian; Wang, Yimeng; Zhang, Christine; Wiebe, Shane; Liu, Alex C H; Ran, Xiaozhuo; Yang, Jiaqi; Naeli, Parisa; Garzia, Aitor; Zhou, Lele; Mahmood, Niaz; Deng, Qiyun; Elaish, Mohamed; Lin, Rongtuan; Mahal, Lara K; Hobman, Tom C; Pelletier, Jerry; Alain, Tommy; Vidal, Silvia M; Duchaine, Thomas; Mazhab-Jafari, Mohammad T; Mao, Xiaojuan; Jafarnejad, Seyed Mehdi; Sonenberg, Nahum.

Proc Natl Acad Sci U S A ; 119(32): e2204539119, 2022 08 09.

Artigo em Inglês | MEDLINE | ID: mdl-35878012

7.

The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo.

Blagih, Julianna; Coulombe, François; Vincent, Emma E; Dupuy, Fanny; Galicia-Vázquez, Gabriela; Yurchenko, Ekaterina; Raissi, Thomas C; van der Windt, Gerritje J W; Viollet, Benoit; Pearce, Erika L; Pelletier, Jerry; Piccirillo, Ciriaco A; Krawczyk, Connie M; Divangahi, Maziar; Jones, Russell G.

Immunity ; 42(1): 41-54, 2015 Jan 20.

Artigo em Inglês | MEDLINE | ID: mdl-25607458

8.

Trans-spliced mRNA products produced from circRNA expression vectors.

Chu, Jennifer; Robert, Francis; Pelletier, Jerry.

RNA ; 27(6): 676-682, 2021 06.

Artigo em Inglês | MEDLINE | ID: mdl-33762403

9.

Therapeutic targeting of eukaryotic initiation factor (eIF) 4E.

Pelletier, Jerry; Sonenberg, Nahum.

Biochem Soc Trans ; 51(1): 113-124, 2023 02 27.

Artigo em Inglês | MEDLINE | ID: mdl-36661272

10.

A comparative study of small molecules targeting eIF4A.

Naineni, Sai Kiran; Itoua Maïga, Rayelle; Cencic, Regina; Putnam, Andrea A; Amador, Luis A; Rodriguez, Abimael D; Jankowsky, Eckhard; Pelletier, Jerry.

RNA ; 26(5): 541-549, 2020 05.

Artigo em Inglês | MEDLINE | ID: mdl-32014999

11.

MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.

Fukao, Akira; Mishima, Yuichiro; Takizawa, Naoki; Oka, Shigenori; Imataka, Hiroaki; Pelletier, Jerry; Sonenberg, Nahum; Thoma, Christian; Fujiwara, Toshinobu.

Mol Cell ; 56(1): 79-89, 2014 Oct 02.

Artigo em Inglês | MEDLINE | ID: mdl-25280105

12.

Assessing eukaryotic initiation factor 4F subunit essentiality by CRISPR-induced gene ablation in the mouse.

Sénéchal, Patrick; Robert, Francis; Cencic, Regina; Yanagiya, Akiko; Chu, Jennifer; Sonenberg, Nahum; Paquet, Marilène; Pelletier, Jerry.

Cell Mol Life Sci ; 78(19-20): 6709-6719, 2021 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-34559254

13.

RNA-tethering assay and eIF4G:eIF4A obligate dimer design uncovers multiple eIF4F functional complexes.

Robert, Francis; Cencic, Regina; Cai, Renying; Schmeing, T Martin; Pelletier, Jerry.

Nucleic Acids Res ; 48(15): 8562-8575, 2020 09 04.

Artigo em Inglês | MEDLINE | ID: mdl-32749456

14.

Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference.

Habibian, Maryam; Harikrishna, S; Fakhoury, Johans; Barton, Maria; Ageely, Eman A; Cencic, Regina; Fakih, Hassan H; Katolik, Adam; Takahashi, Mayumi; Rossi, John; Pelletier, Jerry; Gagnon, Keith T; Pradeepkumar, P I; Damha, Masad J.

Nucleic Acids Res ; 48(9): 4643-4657, 2020 05 21.

Artigo em Inglês | MEDLINE | ID: mdl-32282904

15.

Identification and characterization of hippuristanol-resistant mutants reveals eIF4A1 dependencies within mRNA 5' leader regions.

Steinberger, Jutta; Shen, Leo; J Kiniry, Stephen; Naineni, Sai Kiran; Cencic, Regina; Amiri, Mehdi; Aboushawareb, Sarah A E; Chu, Jennifer; Maïga, Rayelle Itoua; Yachnin, Brahm J; Robert, Francis; Sonenberg, Nahum; Baranov, Pavel V; Pelletier, Jerry.

Nucleic Acids Res ; 48(17): 9521-9537, 2020 09 25.

Artigo em Inglês | MEDLINE | ID: mdl-32766783

16.

Magnesium-sensitive upstream ORF controls PRL phosphatase expression to mediate energy metabolism.

Hardy, Serge; Kostantin, Elie; Wang, Shan Jin; Hristova, Tzvetena; Galicia-Vázquez, Gabriela; Baranov, Pavel V; Pelletier, Jerry; Tremblay, Michel L.

Proc Natl Acad Sci U S A ; 116(8): 2925-2934, 2019 02 19.

Artigo em Inglês | MEDLINE | ID: mdl-30718434

17.

O-GlcNAcylation of core components of the translation initiation machinery regulates protein synthesis.

Li, Xuexia; Zhu, Qiang; Shi, Xiaoliu; Cheng, Yaxian; Li, Xueliu; Xu, Huan; Duan, Xiaotao; Hsieh-Wilson, Linda C; Chu, Jennifer; Pelletier, Jerry; Ni, Maowei; Zheng, Zhiguo; Li, Sihui; Yi, Wen.

Proc Natl Acad Sci U S A ; 116(16): 7857-7866, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30940748

18.

A modular and flexible ESC-based mouse model of pancreatic cancer.

Saborowski, Michael; Saborowski, Anna; Morris, John P; Bosbach, Benedikt; Dow, Lukas E; Pelletier, Jerry; Klimstra, David S; Lowe, Scott W.

Genes Dev ; 28(1): 85-97, 2014 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-24395249

19.

Loss of MYSM1 inhibits the oncogenic activity of cMYC in B cell lymphoma.

Lin, Yun Hsiao; Wang, HanChen; Fiore, Amanda; Förster, Michael; Tung, Lin Tze; Belle, Jad I; Robert, Francis; Pelletier, Jerry; Langlais, David; Nijnik, Anastasia.

J Cell Mol Med ; 25(14): 7089-7094, 2021 07.

Artigo em Inglês | MEDLINE | ID: mdl-34114734

20.

SMARCB1 loss induces druggable cyclin D1 deficiency via upregulation of MIR17HG in atypical teratoid rhabdoid tumors.

Xue, Yibo; Zhu, Xianbing; Meehan, Brian; Venneti, Sriram; Martinez, Daniel; Morin, Geneviève; Maïga, Rayelle I; Chen, Hongbo; Papadakis, Andreas I; Johnson, Radia M; O'Sullivan, Maureen J; Erdreich-Epstein, Anat; Gotlieb, Walter H; Park, Morag; Judkins, Alexander R; Pelletier, Jerry; Foulkes, William D; Rak, Janusz; Huang, Sidong.

J Pathol ; 252(1): 77-87, 2020 09.

Artigo em Inglês | MEDLINE | ID: mdl-32558936

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